5-HT1D receptor

5-HT1D receptor

5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Identifiers
Symbols  ; 5-HT1D; HT1DA; HTR1DA; HTRL; RDC4
External IDs IUPHAR: ChEMBL: GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it.[1] 5-HT1D acts on the central nervous system, and affects locomotion and anxiety. It also induces vascular vasoconstriction in the brain.

Ligands

Agonists

  • 5-(Nonyloxy)tryptamine,[2]
  • sumatriptan (vasoconstrictor in migraine)
  • 5-Carboxamidotryptamine (5-CT)
  • 5-(t-Butyl)-N-methyltryptamine[3]
  • CP-135,807
  • CP-286,601
  • PNU-109,291 ((S)-3,4-Dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-1H-2-benzopyran-6-carboxamide)
  • PNU-142,633 ((1S)-1-[2-[4-[4-(Aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-1H-2-benzopyran-6-carboxamide)
  • GR-46611 (3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide)
  • L-694,247 (2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine)
  • L-772,405

Antagonists

See also

References

  1. ^ "Entrez Gene: HTR1D 5-hydroxytryptamine (serotonin) receptor 1D". 
  2. ^ Glennon RA, Hong SS, Dukat M, Teitler M, Davis K (1994). "5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1Dβ serotonin receptor agonist". Journal of Medicinal Chemistry 37 (18): 2828–2830.  
  3. ^ Xu YC, Schaus JM, Walker C, Krushinski J, Adham N, Zgombick JM, Liang SX, Kohlman DT, Audia JE (1999). "N-Methyl-5-tert-butyltryptamine: A novel, highly potent 5-HT1D receptor agonist". Journal of Medicinal Chemistry 42 (3): 526–531.  

External links

  • "1D"5-HT. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.