Angiopoietin 1

Angiopoietin 1


Angiopoietin 1
Available structures
PDB Ortholog search: RCSB
Identifiers
ANGPT1 Gene
RNA expression pattern

Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1.

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart.[1]

Interactions

Angiopoietin 1 has been shown to interact with TEK tyrosine kinase.[2][3][4][5]

See also

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.