|
|
|
|
5-HT1A
|
-
Agonists: 8-OH-DPAT
-
Adatanserin
-
Amphetamine
-
Antidepressants (e.g., etoperidone, nefazodone, trazodone, vilazodone, vortioxetine)
-
Atypical antipsychotics (e.g., aripiprazole, asenapine, clozapine, lurasidone, quetiapine, ziprasidone)
-
Azapirones (e.g., buspirone, eptapirone, gepirone, perospirone, tandospirone)
-
Bay R 1531
-
Befiradol
-
BMY-14802
-
Cannabidiol
-
Dimemebfe
-
Dopamine
-
Ebalzotan
-
Eltoprazine
-
Ergolines (e.g., bromocriptine, cabergoline, dihydroergotamine, ergotamine, lisuride, LSD, methylergometrine (methylergonovine), methysergide, pergolide)
-
F-11461
-
F-12826
-
F-13714
-
F-14679
-
F-15063
-
F-15599
-
Flesinoxan
-
Flibanserin
-
Lesopitron
-
LY-293284
-
LY-301317
-
mCPP
-
MKC-242
-
Naluzotan
-
NBUMP
-
Osemozotan
-
Oxaflozane
-
Pardoprunox
-
Piclozotan
-
Rauwolscine
-
Repinotan
-
Roxindole
-
RU-24969
-
S-14506
-
S-14671
-
S-15535
-
Sarizotan
-
Serotonin (5-HT)
-
SSR-181507
-
Sunepitron
-
Tryptamines (e.g., 5-CT, 5-MeO-DMT, 5-MT, bufotenin, DMT, indorenate, N-Me-5-HT, psilocin, psilocybin)
-
U-92016A
-
Urapidil
-
Vilazodone
-
Xaliproden
-
Yohimbine
|
|
-
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole)
-
AV965
-
Beta blockers (e.g., alprenolol, cyanopindolol, iodocyanopindolol, oxprenolol, pindobind, pindolol, propranolol, tertatolol)
-
BMY-7378
-
CSP-2503
-
Dotarizine
-
Ergolines (e.g., metergoline)
-
Flopropione
-
GR-46611
-
Isamoltane
-
Lecozotan
-
Mefway
-
Metitepine (methiothepin)
-
MIN-117
-
MPPF
-
NAN-190
-
Robalzotan
-
S-15535
-
SB-649915
-
SDZ 216-525
-
Spiperone
-
Spiramide
-
Spiroxatrine
-
UH-301
-
WAY-100135
-
WAY-100635
-
Xylamidine
|
|
|
|
|
5-HT1B
|
-
Agonists: CGS-12066A
-
CP-93129
-
CP-94253
-
CP-122,288
-
CP-135807
-
Eltoprazine
-
Ergolines (e.g., bromocriptine, dihydroergotamine, ergotamine, methylergometrine (methylergonovine), methysergide, pergolide)
-
mCPP
-
RU-24969
-
Serotonin (5-HT)
-
Triptans (e.g., avitriptan, donitriptan, eletriptan, sumatriptan, zolmitriptan)
-
TFMPP
-
Tryptamines (e.g., 5-BT, 5-CT, 5-MT, DMT)
-
Vortioxetine
|
|
|
|
|
|
|
5-HT1D
|
-
Agonists: CP-122,288
-
CP-135807
-
CP-286601
-
Ergolines (e.g., bromocriptine, cabergoline, dihydroergotamine, ergotamine, LSD, methysergide)
-
GR-46611
-
L-694247
-
L-772405
-
mCPP
-
PNU-109291
-
PNU-142633
-
Serotonin (5-HT)
-
Triptans (e.g., almotriptan, avitriptan, donitriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan)
-
Tryptamines (e.g., 5-BT, 5-CT, 5-Et-DMT, 5-MT, 5-(nonyloxy)tryptamine, DMT)
|
|
|
|
|
|
|
5-HT1E
|
|
|
5-HT1F
|
|
|
|
|
|
|
5-HT2A
|
-
Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe, 25CN-NBOH, 2CBFly-NBOMe)
-
2Cs (e.g., 2C-B, 2C-E, 2C-I, 2C-T-2, 2C-T-7, 2C-T-21)
-
2C-B-FLY
-
2CB-Ind
-
5-Methoxytryptamines (5-MeO-DET, 5-MeO-DiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MT)
-
α-Alkyltryptamines (e.g., 5-Cl-αMT, 5-Fl-αMT, 5-MeO-αET, 5-MeO-αMT, α-Me-5-HT, αET, αMT)
-
AL-34662
-
AL-37350A
-
Bromo-DragonFLY
-
Dimemebfe
-
DMBMPP
-
DOx (e.g., DOB, DOC, DOI, DOM)
-
Efavirenz
-
Ergolines (e.g., 1P-LSD, ALD-52, bromocriptine, cabergoline, ergine (LSA), ergotamine, lisuride, LA-SS-Az, LSB, LSD, LSD-Pip, LSH, LSP, methylergometrine (methylergonovine), pergolide)
-
Jimscaline
-
Lorcaserin
-
MDxx (e.g., MDA, MDMA, MDOH, MMDA)
-
Medifoxamine
-
O-4310
-
Oxaflozane
-
PHA-57378
-
PNU-22394
-
PNU-181731
-
RH-34
-
Phenethylamines (e.g., lophophine, mescaline)
-
Piperazines (e.g., BZP, mCPP, quipazine, TFMPP)
-
Serotonin (5-HT)
-
TCB-2
-
TFMFly
-
Tryptamines (e.g., 5-BT, 5-CT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)
|
|
-
Antagonists: 5-I-R91150
-
5-MeO-NBpBrT
-
AC-90179
-
Adatanserin
-
Altanserin
-
AMDA
-
APD-215
-
Atypical antipsychotics (e.g., amperozide, aripiprazole, asenapine, blonanserin, carpipramine, clocapramine, clorotepine, clozapine, fluperlapine, gevotroline, iloperidone, melperone, mosapramine, olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine, ziprasidone, zotepine)
-
Cinanserin
-
CSP-2503
-
Cyproheptadine
-
Deramciclane
-
Dotarizine
-
Eplivanserin
-
Ergolines (e.g., amesergide, LY-53857, LY-215840, mesulergine, metergoline, methysergide, sergolexole)
-
Etoperidone
-
Fananserin
-
Flibanserin
-
Glemanserin
-
Irindalone
-
Ketanserin
-
KML-010
-
Lubazodone
-
LY-393558
-
Mepiprazole
-
Metitepine (methiothepin)
-
MIN-101
-
Nantenine
-
Nefazodone
-
Phenoxybenzamine
-
Pimavanserin
-
Pirenperone
-
Pizotifen
-
Pruvanserin
-
Rauwolscine
-
Ritanserin
-
S-14671
-
Sarpogrelate
-
Setoperone
-
Spiperone
-
Spiramide
-
SR-46349B
-
Teniloxazine
-
Temanogrel
-
Tetracyclic antidepressants (e.g., amoxapine, aptazapine, esmirtazapine, maprotiline, mianserin, mirtazapine)
-
Trazodone
-
Tricyclic antidepressants (e.g., amitriptyline)
-
Typical antipsychotics (e.g., chlorpromazine, fluphenazine, haloperidol, loxapine, perphenazine, pimozide, pipamperone, prochlorperazine, thioridazine, thiothixene, trifluoperazine)
-
Volinanserin
-
Xylamidine
-
Yohimbine
|
|
|
|
|
5-HT2B
|
-
Agonists: 4-Methylaminorex
-
Aminorex
-
Amphetamines (eg., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine)
-
BW-723C86
-
DOx (e.g., DOB, DOC, DOI, DOM)
-
Ergolines (e.g., cabergoline, dihydroergocryptine, dihydroergotamine, ergotamine, methylergometrine (methylergonovine), methysergide, pergolide)
-
MDxx (e.g., MDA, MDMA, MDOH, MMDA)
-
Piperazines (e.g., mCPP)
-
PNU-22394
-
Ro60-0175
-
Serotonin (5-HT)
-
Tryptamines (e.g., 5-BT, 5-CT, 5-MT, α-Me-5-HT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)
|
|
|
|
|
|
|
5-HT2C
|
-
Agonists: 2Cs (e.g., 2C-B, 2C-E, 2C-I, 2C-T-2, 2C-T-7, 2C-T-21)
-
5-Methoxytryptamines (5-MeO-DET, 5-MeO-DiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MT)
-
α-Alkyltryptamines (e.g., 5-Cl-αMT, 5-Fl-αMT, 5-MeO-αET, 5-MeO-αMT, α-Me-5-HT, αET, αMT)
-
A-372159
-
AL-38022A
-
Alstonine
-
CP-809101
-
Dimemebfe
-
DOx (e.g., DOB, DOC, DOI, DOM)
-
Ergolines (e.g., ALD-52, cabergoline, dihydroergotamine, ergine (LSA), ergotamine, lisuride, LA-SS-Az, LSB, LSD, LSD-Pip, LSH, LSP, pergolide)
-
Lorcaserin
-
MDxx (e.g., MDA, MDMA, MDOH, MMDA)
-
Medifoxamine
-
MK-212
-
Org 12962
-
Org 37684
-
Oxaflozane
-
PHA-57378
-
Phenethylamines (e.g., lophophine, mescaline)
-
Piperazines (e.g., aripiprazole, BZP, mCPP, quipazine, TFMPP)
-
PNU-22394
-
PNU-181731
-
Ro60-0175
-
Ro60-0213
-
Serotonin (5-HT)
-
Tryptamines (e.g., 5-BT, 5-CT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)
-
Vabicaserin
-
WAY-629
-
WAY-161503
-
YM-348
|
|
-
Antagonists: Adatanserin
-
Agomelatine
-
Atypical antipsychotics (e.g., asenapine, clorotepine, clozapine, fluperlapine, iloperidone, melperone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, ziprasidone, zotepine)
-
Captodiame
-
CEPC
-
Cinanserin
-
Cyproheptadine
-
Deramciclane
-
Dotarizine
-
Eltoprazine
-
Ergolines (e.g., amesergide, bromocriptine, LY-53857, LY-215840, mesulergine, metergoline, methysergide, sergolexole)
-
Etoperidone
-
Fluoxetine
-
FR-260010
-
Irindalone
-
Ketanserin
-
Ketotifen
-
Latrepirdine (dimebolin)
-
Metitepine (methiothepin)
-
Nefazodone
-
Pirenperone
-
Pizotifen
-
Propranolol
-
Ritanserin
-
RS-102221
-
S-14671
-
SB-200646
-
SB-206553
-
SB-221284
-
SB-228357
-
SB-242084
-
SB-243213
-
SDZ SER-082
-
Tedatioxetine
-
Tetracyclic antidepressants (e.g., amoxapine, aptazapine, esmirtazapine, maprotiline, mianserin, mirtazapine)
-
TIK-301
-
Trazodone
-
Tricyclic antidepressants (e.g., amitriptyline, nortriptyline)
-
Typical antipsychotics (e.g., chlorpromazine, loxapine, pimozide, pipamperone, thioridazine)
-
Xylamidine
|
|
|
|
|
|
|
|
|
5-HT3
|
-
Agonists: Alcohols (e.g., butanol, ethanol, trichloroethanol)
-
m-CPBG
-
Phenylbiguanide
-
Piperazines (e.g., BZP, mCPP, quipazine)
-
RS-56812
-
Serotonin (5-HT)
-
SR-57227
-
SR-57227A
-
Tryptamines (e.g., 2-Me-5-HT, 5-CT, bufotenidine (5-HTQ))
-
Volatiles/gases (e.g., halothane, isoflurane, toluene, trichloroethane)
-
YM-31636
|
|
-
Antagonists: Alosetron
-
AS-8112
-
Atypical antipsychotics (e.g., clozapine, olanzapine, quetiapine)
-
Azasetron
-
Batanopride
-
Bemesetron (MDL-72222)
-
Cilansetron
-
CSP-2503
-
Dazopride
-
Dolasetron
-
Galanolactone
-
Granisetron
-
ICS-205930
-
Lerisetron
-
Memantine
-
Ondansetron
-
Palonosetron
-
Ramosetron
-
Renzapride
-
Ricasetron
-
Tedatioxetine
-
Tetracyclic antidepressants (e.g., amoxapine, mianserin, mirtazapine)
-
Thujone
-
Tropanserin
-
Tropisetron
-
Typical antipsychotics (e.g., loxapine)
-
Volatiles/gases (e.g., nitrous oxide, sevoflurane, xenon)
-
Vortioxetine
-
Zacopride
-
Zatosetron
|
|
|
|
|
5-HT4
|
|
|
5-HT5A
|
|
|
5-HT6
|
-
Agonists: Ergolines (e.g., dihydroergocryptine, dihydroergotamine, ergotamine, lisuride, LSD, mesulergine, metergoline, methysergide)
-
Serotonin (5-HT)
-
Tryptamines (e.g., 2-Me-5-HT, 5-BT, 5-CT, 5-MT, Bufotenin, E-6801, E-6837, EMD-386088, EMDT, LY-586713, N-Me-5-HT, tryptamine)
-
WAY-181187
-
WAY-208466
|
|
-
Antagonists: ABT-354
-
Atypical antipsychotics (e.g., aripiprazole, asenapine, clorotepine, clozapine, fluperlapine, iloperidone, olanzapine, tiospirone)
-
AVN-101
-
AVN-211
-
AVN-322
-
AVN-397
-
BGC20-760
-
BVT-5182
-
BVT-74316
-
Cerlapirdine
-
EGIS-12233
-
GW-742457
-
Idalopirdine
-
Ketanserin
-
Latrepirdine (dimebolin)
-
Metitepine (methiothepin)
-
MS-245
-
PRX-07034
-
Ritanserin
-
Ro04-6790
-
Ro 63-0563
-
SB-258585
-
SB-271046
-
SB-357134
-
SB-399885
-
SB-742457
-
Tetracyclic antidepressants (e.g., amoxapine, mianserin)
-
Tricyclic antidepressants (e.g., amitriptyline, clomipramine, doxepin, nortriptyline)
-
Typical antipsychotics (e.g., chlorpromazine, loxapine)
|
|
|
|
|
5-HT7
|
|
|
-
Antagonists: Atypical antipsychotics (e.g., amisulpride, aripiprazole, asenapine, clorotepine, clozapine, fluperlapine, olanzapine, risperidone, sertindole, tiospirone, ziprasidone, zotepine)
-
Butaclamol
-
DR-4485
-
EGIS-12233
-
Ergolines (e.g., 2-Br-LSD (BOL-148), amesergide, bromocriptine, cabergoline, dihydroergotamine, ergotamine, LY-53857, LY-215840, mesulergine, metergoline, methysergide, sergolexole)
-
Ketanserin
-
LY-215840
-
Metitepine (methiothepin)
-
Ritanserin
-
SB-258719
-
SB-258741
-
SB-269970
-
SB-656104
-
SB-656104A
-
SB-691673
-
SLV-313
-
SLV-314
-
Spiperone
-
SSR-181507
-
Tetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin, mirtazapine)
-
Tricyclic antidepressants (e.g., amitriptyline, clomipramine, imipramine)
-
Typical antipsychotics (e.g., acetophenazine, chlorpromazine, chlorprothixene, fluphenazine, loxapine, pimozide)
-
Vortioxetine
|
|
|
|
|
|
|
|
|
SERT
|
|
|
|
|
|
|
|
|
-
Others: A-80426
-
Amoxapine
-
Antihistamines (e.g., brompheniramine, chlorphenamine, dimenhydrinate, diphenhydramine, mepyramine (pyrilamine), pheniramine, tripelennamine)
-
Arylcyclohexylamines (e.g., ketamine, phencyclidine)
-
CP-39332
-
Cyclobenzaprine
-
Dextromethorphan
-
Dextrorphan
-
Efavirenz
-
Etoperidone
-
EXP-561
-
Fezolamine
-
LY-393558
-
Litoxetine
-
Loxapine
-
Lubazodone
-
Mesembrine
-
Mifepristone
-
MIN-117
-
N-Me-5-HT
-
Nefazodone
-
Nefopam
-
Opioids (e.g., dextropropoxyphene, methadone, pethidine (meperidine))
-
PIM-35
-
Pridefine
-
Roxindole
-
SB-649915
-
Tofenacin
-
Trazodone
-
Tropanes (e.g., cocaine)
-
Vilazodone
-
Vortioxetine
-
Ziprasidone
|
|
|
VMATs
|
|
|
|
|
|
|
|
|
|
|
|
|