Beta-3 adrenergic receptor
|Adrenoceptor beta 3|
|RNA expression pattern|
Actions of the β3 receptor include:
It is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Some β3 agonists have demonstrated antistress effects in animal studies, suggesting it also has a role in the central nervous system (CNS). Beta3-Receptors are found in the gallbladder, urinary bladder, and in brown adipose tissue. Their role in gallbladder physiology is unknown, but they are thought to play a role in lipolysis and thermogenesis in brown fat. In the urinary bladder it is thought to cause relaxation of the bladder and prevention of urination.
Mechanism of action
- Mirabegron (YM-178), approved for treatment of overactive bladder in Japan, the United States, and Canada.
- SR 59230A was thought to be a selective β3 antagonist but later found to also be an antagonist of the α1 receptor.
- Other adrenergic receptors
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