C5a receptor
| Complement component 5a receptor 1 | |||||||||||||
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| Symbols | ; C5A; C5AR; C5R1; CD88 | ||||||||||||
| External IDs | IUPHAR: ChEMBL: GeneCards: | ||||||||||||
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| Species | Human | Mouse | |||||||||||
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The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a. It functions as a complement receptor.[1]
C5a receptor structure and its residues possessing role in ligand binding or signaling.
Cells
The C5a receptor is expressed on:[2]
- Granulocytes
- Monocytes
- Dendritic cells
- Hepatoma-derived cell line HepG2
- Astrocytes
- Microglia
See also
- Complement component 5a for binding mechanism
References
- ^ Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor". Annu. Rev. Immunol. 12: 775–808.
- ^ Klos A, Wende E, Wareham KJ, Monk PN. (2013). "International Union of Pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacol. Rev. 65 (1): 500–43.
Further reading
- Sengeløv H (1996). "Complement receptors in neutrophils.". Crit. Rev. Immunol. 15 (2): 107–31.
- Beil WJ, Schulz M, Wefelmeyer U (2001). "Mast cell granule composition and tissue location--a close correlation.". Histol. Histopathol. 15 (3): 937–46.
- Yamamoto T (2007). "Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes.". Pathol. Int. 57 (1): 1–11.
- Bao L, Gerard NP, Eddy RL, et al. (1992). "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.". Genomics 13 (2): 437–40.
- Gerard NP, Gerard C (1991). "The chemotactic receptor for human C5a anaphylatoxin.". Nature 349 (6310): 614–7.
- Boulay F, Mery L, Tardif M, et al. (1991). "Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells.". Biochemistry 30 (12): 2993–9.
- Wahl SM, Allen JB, Gartner S, et al. (1989). "HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes.". J. Immunol. 142 (10): 3553–9.
- Foreman KE, Vaporciyan AA, Bonish BK, et al. (1994). "C5a-induced expression of P-selectin in endothelial cells.". J. Clin. Invest. 94 (3): 1147–55.
- Giannini E, Brouchon L, Boulay F (1995). "Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo.". J. Biol. Chem. 270 (32): 19166–72.
- Buhl AM, Osawa S, Johnson GL (1995). "Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor.". J. Biol. Chem. 270 (34): 19828–32.
- Wennogle LP, Conder L, Winter C, et al. (1994). "Stabilization of C5a receptor--G-protein interactions through ligand binding.". J. Cell. Biochem. 55 (3): 380–8.
- Gerard NP, Bao L, Xiao-Ping H, et al. (1993). "Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene.". Biochemistry 32 (5): 1243–50.
- Ames RS, Li Y, Sarau HM, et al. (1996). "Molecular cloning and characterization of the human anaphylatoxin C3a receptor.". J. Biol. Chem. 271 (34): 20231–4.
- Werfel T, Zwirner J, Oppermann M, et al. (1996). "CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin.". J. Immunol. 157 (4): 1729–35.
- Höpken UE, Lu B, Gerard NP, Gerard C (1996). "The C5a chemoattractant receptor mediates mucosal defence to infection.". Nature 383 (6595): 86–9.
- Chen Z, Zhang X, Gonnella NC, et al. (1998). "Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin.". J. Biol. Chem. 273 (17): 10411–9.
- Floreani AA, Heires AJ, Welniak LA, et al. (1998). "Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke.". J. Immunol. 160 (10): 5073–81.
- Ottonello L, Corcione A, Tortolina G, et al. (1999). "rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues.". J. Immunol. 162 (11): 6510–7.
- Kohleisen B, Shumay E, Sutter G, et al. (2000). "Stable expression of HIV-1 Nef induces changes in growth properties and activation state of human astrocytes.". AIDS 13 (17): 2331–41.
- Monk PN, Scola A-M, Madala P, Fairlie DP (2007). "Function, structure and therapeutic potential of complement C5a receptors". British Journal of Pharmacology 152 (4): 429–48.
External links
- "Anaphylatoxin Receptors: C5a". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- C5a receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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