CCR1

CCR1

Chemokine (C-C motif) receptor 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; CD191; CKR-1; CKR1; CMKBR1; HM145; MIP1aR; SCYAR1
External IDs IUPHAR: ChEMBL: GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene.[1]

CCR1 has also recently been designated CD191 (cluster of differentiation 191). This gene encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors, which mediate signal transduction, are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on chromosome 3p.[2]

Interactions

CCR1 has been shown to interact with CCL5.[3][4]

References

  1. ^ Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ (Mar 1993). "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor". Cell 72 (3): 415–25.  
  2. ^ "Entrez Gene: CCR1 chemokine (C-C motif) receptor 1". 
  3. ^ Struyf, S; Menten P, Lenaerts J P, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (Jul 2001). "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". Eur. J. Immunol. (Germany) 31 (7): 2170–8.  
  4. ^ Proudfoot, A E; Fritchley S; Borlat F; Shaw J P; Vilbois F; Zwahlen C; Trkola A; Marchant D; Clapham P R; Wells T N (Apr 2001). "The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity". J. Biol. Chem. (United States) 276 (14): 10620–6.  

Further reading

External links

  • "Chemokine Receptors: CCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.