|Chemokine (C-C motif) receptor 1|
|Symbols||; CD191; CKR-1; CKR1; CMKBR1; HM145; MIP1aR; SCYAR1|
|External IDs||IUPHAR: ChEMBL: GeneCards:|
|RNA expression pattern|
CCR1 has also recently been designated CD191 (cluster of differentiation 191). This gene encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors, which mediate signal transduction, are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on chromosome 3p.
- Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ (Mar 1993). "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor". Cell 72 (3): 415–25.
- "Entrez Gene: CCR1 chemokine (C-C motif) receptor 1".
- Struyf, S; Menten P, Lenaerts J P, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (Jul 2001). "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". Eur. J. Immunol. (Germany) 31 (7): 2170–8.
- Proudfoot, A E; Fritchley S; Borlat F; Shaw J P; Vilbois F; Zwahlen C; Trkola A; Marchant D; Clapham P R; Wells T N (Apr 2001). "The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity". J. Biol. Chem. (United States) 276 (14): 10620–6.
- Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor.". Annu. Rev. Immunol. 12 (1): 775–808.
- Ruibal-Ares BH, Belmonte L, Baré PC, et al. (2004). "HIV-1 infection and chemokine receptor modulation.". Curr. HIV Res. 2 (1): 39–50.
- Nomura H, Nielsen BW, Matsushima K (1994). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors.". Int. Immunol. 5 (10): 1239–49.
- Ben-Baruch A, Xu L, Young PR, et al. (1995). "Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3.". J. Biol. Chem. 270 (38): 22123–8.
- Post TW, Bozic CR, Rothenberg ME, et al. (1995). "Molecular characterization of two murine eosinophil beta chemokine receptors.". J. Immunol. 155 (11): 5299–305.
- Gao JL, Kuhns DB, Tiffany HL, et al. (1993). "Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.". J. Exp. Med. 177 (5): 1421–7.
- Combadiere C, Ahuja SK, Van Damme J, et al. (1996). "Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B.". J. Biol. Chem. 270 (50): 29671–5.
- Kuang Y, Wu Y, Jiang H, Wu D (1996). "Selective G protein coupling by C-C chemokine receptors.". J. Biol. Chem. 271 (8): 3975–8.
- Boring L, Gosling J, Monteclaro FS, et al. (1996). "Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9.". J. Biol. Chem. 271 (13): 7551–8.
- Gong X, Gong W, Kuhns DB, et al. (1997). "Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptors.". J. Biol. Chem. 272 (18): 11682–5.
- Daugherty BL, Springer MS (1997). "The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21.". Genomics 41 (2): 294–5.
- Pakianathan DR, Kuta EG, Artis DR, et al. (1997). "Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5.". Biochemistry 36 (32): 9642–8.
- Coulin F, Power CA, Alouani S, et al. (1997). "Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines.". Eur. J. Biochem. 248 (2): 507–15.
- Youn BS, Zhang SM, Broxmeyer HE, et al. (1998). "Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1.". Blood 91 (9): 3118–26.
- Nardelli B, Tiffany HL, Bong GW, et al. (1999). "Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1.". J. Immunol. 162 (1): 435–44.
- Shaw KT, Greig NH (1999). "Chemokine receptor mRNA expression at the in vitro blood–brain barrier during HIV infection.". Neuroreport 10 (1): 53–6.
- Zhang S, Youn BS, Gao JL, et al. (1999). "Differential effects of leukotactin-1 and macrophage inflammatory protein-1 alpha on neutrophils mediated by CCR1.". J. Immunol. 162 (8): 4938–42.
- Lalani AS, Masters J, Zeng W, et al. (1999). "Use of chemokine receptors by poxviruses.". Science 286 (5446): 1968–71.
- "Chemokine Receptors: CCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.