A calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels.
Comparison tables 1
- Voltage-gated 1.1
- Ligand-gated 1.2
- Pharmacology 2
- References 3
- External links 4
The following tables explain gating, gene, location and function of different types of calcium channels, both voltage and ligand-gated.
|Type||Voltage||α1 subunit (gene name)||Associated subunits||Most often found in|
|L-type calcium channel ("Long-Lasting" AKA "DHP Receptor")||HVA (high voltage activated)||
Cav1.2 (CACNA1C) Cav1.3 (CACNA1D)
|α2δ, β, γ||Skeletal muscle, smooth muscle, bone (osteoblasts), ventricular myocytes** (responsible for prolonged action potential in cardiac cell; also termed DHP receptors), dendrites and dendritic spines of cortical neurones|
|P-type calcium channel ("Purkinje") /Q-type calcium channel||HVA (high voltage activated)||Cav2.1 (CACNA1A)||α2δ, β, possibly γ||Purkinje neurons in the cerebellum / Cerebellar granule cells|
|N-type calcium channel ("Neural"/"Non-L")||HVA (high-voltage-activated)||Cav2.2 (CACNA1B)||α2δ/β1, β3, β4, possibly γ||Throughout the brain and peripheral nervous system.|
|R-type calcium channel ("Residual")||intermediate-voltage-activated||Cav2.3 (CACNA1E)||α2δ, β, possibly γ||Cerebellar granule cells, other neurons|
|T-type calcium channel ("Transient")||low-voltage-activated||
|neurons, cells that have pacemaker activity, bone (osteocytes), thalamus (thalamus)|
|IP3 receptor||IP3||ITPR1, ITPR2, ITPR3||ER/SR||Releases calcium from ER/SR in response to IP3 by e.g. GPCRs|
|Ryanodine receptor||dihydropyridine receptors in T-tubules and increased intracellular calcium (Calcium Induced Calcium Release - CICR)||RYR1, RYR2, RYR3||ER/SR||Calcium-induced calcium release in myocytes|
|Cation channels of sperm|
|store-operated channels||indirectly by ER/SR depletion of calcium||ORAI1, ORAI2, ORAI3||plasma membrane|
- "calcium channel" at Dorland's Medical Dictionary
- Striggow F, Ehrlich BE (August 1996). "Ligand-gated calcium channels inside and out". Curr. Opin. Cell Biol. 8 (4): 490–5.
- Walter F., PhD. Boron (2005). Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. Page 479
- Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. Page 53
- "Voltage-Gated Ion Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- "TRIP Database". a manually curated database of protein-protein interactions for mammalian TRP channels.
- Calcium Channels at the US National Library of Medicine Medical Subject Headings (MeSH)