Calsenilin

Calsenilin

Kv channel interacting protein 3, calsenilin
Available structures
PDB Ortholog search: RCSB
Identifiers
KCNIP3 Gene
Orthologs
SpeciesHumanMouse

Calsenilin is a protein that in humans is encoded by the KCNIP3 gene.[1][2][3]

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins.[4][5] Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.[3]

Interactions

Calsenilin has been shown to interact with PSEN1[1][6] and PSEN2.[1][7]

See also

References

Further reading

External links

  • Medical Subject Headings (MeSH)
  • NCS proteins

This article incorporates text from the United States National Library of Medicine, which is in the public domain.