Class C GPCR

Class C GPCR

7 transmembrane receptor (metabotropic glutamate family)
Identifiers
Symbol 7tm_3
Pfam InterPro PROSITE PDOC00754

The class C G-protein-coupled receptors (

Family C GPCRs have a large extracellular N-terminus which binds the orthosteric (endogenous) ligand. The shape of this domain is often likened to a clam. Several allosteric ligands to these receptors have been identified and these bind within the seven transmembrane region.

Subfamilies

Calcium-sensing receptor-related

  • extracellular calcium-sensing receptor-related IPR000068
    • CASR)
    • GPRC6A)

GABAB receptors

  • IPR002455
    • GABBR1)
    • GABBR2)

Metabotropic glutamate receptors

  • IPR000162
    • GRM1)
    • GRM2)
    • GRM3)
    • GRM4)
    • GRM5)
    • GRM6)
    • GRM7)
    • GRM8)

RAIG

Taste receptors

Orphan

Other

  • Bride of sevenless protein IPR002956
  • IPR004073

References