Coagulation factor ii receptor

Coagulation factor II (thrombin) receptor
1NRN
Available structures
PDB Ortholog search: RCSB
Identifiers
F2R Gene
RNA expression pattern
"F2R" redirects here. For the Navy fighter, see Ryan XF2R Dark Shark.

Proteinase-activated receptor 1 (PAR1) also known as the coagulation factor II (thrombin) receptor is a protein that in humans is encoded by the F2R gene.[1] PAR1 is a G protein-coupled receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor.[2]

Ligands

Several selective antagonists for the PAR1 receptor have been developed, for use as anti-clotting agents for the treatment of heart disease.

  • SCH-530,348

See also

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.