|Systematic (IUPAC) name|
2-(chloromethyl)oxirane 2-methyl-1H-imidazole copolymer
|CAS Registry Number|
Colestilan is contraindicated in patients with bowel obstruction.
The substance can inhibit the resorption of other drugs, as well as fat soluble vitamins (A, D, E, K) and folate, from the gut. Resulting lower blood levels can be clinically problematic with immunosuppressant and antiepileptic drugs.
Chemistry and mechanism of action
Colestilan is a cross-linked copolymer of 2-methylimidazole and epichlorohydrin and works as an anion exchanger resin with affinity to phosphate, bile acid anions and urate. It binds these anions in the gut and removes them from the enterohepatic circulation. Colestilan is not absorbed from the gut, but is excreted together with the bound anions.