Cysteinyl leukotriene receptor 1

Cysteinyl leukotriene receptor 1

Cysteinyl leukotriene receptor 1
Identifiers
CYSLTR1 Gene
Orthologs
SpeciesHumanMouse

Cysteinyl leukotriene receptor 1 is a protein that in humans is encoded by the CYSLTR1 gene.[1][2][3]

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors and uses a phosphatidylinositol-calcium second messenger system.[4] Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.[3]

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Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.