EMR1

EMR1

Egf-like module containing, mucin-like, hormone receptor-like 1
Identifiers
EMR1 Gene
RNA expression pattern

EGF-like module-containing mucin-like hormone receptor-like 1 is a protein that in humans is encoded by the EMR1 gene.[1][2][3] The mouse homologue is known as F4/80.[4]

Function

This gene encodes a protein that is a member of the adhesion-GPCR family. [5] Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 region via membrane proximal GAIN domain. In the case of EMR1 these domains are Epidermal Growth Factor (EGF-like) domains.

Emr1 is a transmembrane protein present on the cell-surface of human macrophages, which are derived from the myeloid lineage. It has an approximate mass of 125 kDa, and is associated with mature macrophages.

See also

References

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.