Egf-like module containing, mucin-like, hormone receptor-like 3
EMR3 Gene
RNA expression pattern

EGF-like module-containing mucin-like hormone receptor-like 3 is a protein that in humans is encoded by the EMR3 gene.[1]


The gene product is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. In the case of EMR3, the N-terminal protein domains consists of 2 epidermal growth factor (EGF)-like domains. [2] [3] EMR3 is expressed predominantly by cells of the immune system. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 EMR2 on chromosome 19. The protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.[4]

See also


Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.