FZD6
| Frizzled family receptor 6 | |||||||||||||
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| Identifiers | |||||||||||||
| FZD6 Gene | |||||||||||||
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| RNA expression pattern | |||||||||||||
Frizzled-6 is a protein that in humans is encoded by the FZD6 gene.[1][2][3]
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif.[3] The FZD6 protein is believed to be the receptor for the WNT4 ligand.[4]
Phenotypes
In 2004, researchers at the Howard Hughes Medical Institute showed that FZD6 controls hair patterning in mice,[3] and its human homologue is understood to play a part in the formation of hair whorls and cowlicks.
Interactions
FZD6 has been shown to interact with Secreted frizzled-related protein 1.[5]
See also
References
External links
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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