FZD6

FZD6

Frizzled family receptor 6
Identifiers
FZD6 Gene
RNA expression pattern

Frizzled-6 is a protein that in humans is encoded by the FZD6 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif.[3] The FZD6 protein is believed to be the receptor for the WNT4 ligand.[4]

Phenotypes

In 2004, researchers at the Howard Hughes Medical Institute showed that FZD6 controls hair patterning in mice,[3] and its human homologue is understood to play a part in the formation of hair whorls and cowlicks.

Interactions

FZD6 has been shown to interact with Secreted frizzled-related protein 1.[5]

See also

References

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.