FZD7

FZD7

Frizzled family receptor 7
Identifiers
FZD7 Gene
RNA expression pattern

Frizzled-7 is a protein that in humans is encoded by the FZD7 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.[3]

Interactions

FZD7 has been shown to interact with DLG4.[4]

See also

References

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.