Ganglionic blocker

Ganglionic blocker

A ganglionic blocker (or ganglioplegic) is a type of medication that inhibits postganglionic transmission, primarily by acting as a nicotinic antagonist.[1]

Because ganglionic blockers block the

  1. ^ Ganglionic blockers at the US National Library of Medicine Medical Subject Headings (MeSH)
  2. ^ "PHARMACOLOGY OF GANGLIONIC TRANSMISSION, 1998". Archived from the original on 2008-05-01. Retrieved 2008-10-04. 
  3. ^ Drill's Pharmacology in Medicine, 4th Ed. (1971). J. R. DiPalma (Ed.), pp. 723-724, New York: McGraw-Hill.
  4. ^ MeSH list of agents 82005730


  • Cardiovascular: Orthostatic(postural) hypotension, Tachycardia
  • GIT: Dry-mouth, GIT atony,urine retention, digestive problems
  • Sexual Dysfunction: Failure of erection and ejaculation


Ganglionic blockers are used less frequently now than they were in the past, because more selective agents are now available. However, they are still used in some emergency situations, such as aortic dissection or autonomic dysreflexia.


Others include:[4]

The first ganglion-blocker to be used clinically was tetraethylammonium, although it was soon superseded by better drugs.[3] Other examples include hexamethonium, pentolinium, mecamylamine, trimetaphan, and pempidine.



  • Examples 1
  • Uses 2
  • Side-Effects 3
  • References 4