Genetically modified food
Genetically modified foods or GM foods, also genetically engineered foods, are foods produced from DNA using the methods of genetic engineering. Genetic engineering techniques allow for the introduction of new traits as well as greater control over traits than previous methods such as selective breeding and mutation breeding.
Commercial sale of genetically modified foods began in 1994, when Calgene first marketed its Flavr Savr delayed-ripening tomato. Most food modifications have primarily focused on cash crops in high demand by farmers such as soybean, corn, canola, and cotton seed oil. Genetically modified crops have been engineered for resistance to pathogens and herbicides and for better nutrient profiles. GM livestock have been developed, although as of November 2013 none were on the market.
There is general scientific agreement that food from genetically modified crops is not inherently riskier to human health than conventional food. However, there are ongoing public concerns related to food safety, regulation, labelling, environmental impact, research methods, and the fact that some GM seeds are subject to intellectual property rights owned by corporations.
- Definition 1
- History 2
- Process 3
- Fruits and vegetables 4.1
- Corn 4.2
- Soy 4.3
Derivative products 5
- Corn starch and starch sugars, including syrups 5.1
- Lecithin 5.2
- Sugar 5.3
- Vegetable oil 5.4
Other uses 6
- Animal feed 6.1
- Proteins 6.2
- Livestock 6.3
- Controversies 7
- Testing 8
- Labeling 9.1
- Detection 10
- See also 11
- References 12
- External links 13
Genetically modified foods, GM foods or genetically engineered foods, are foods produced from organisms that have had changes introduced into their DNA using the methods of genetic engineering as opposed to traditional cross breeding. In the US, the Department of Agriculture (USDA) and the Food and Drug Administration (FDA) favor the use of "genetic engineering" over "genetic modification" as the more precise term; the USDA defines genetic modification to include "genetic engineering or other more traditional methods."
According to the 
Food biotechnology is a branch of food science that seeks to improve foods and food production. Associated processes include industrial fermentation, cross breeding, plant cultures and genetic engineering.
Food biotechnology dates back to the time of the
- Documentary on YouTube
- Library resources in your library and in other libraries about Genetically modified food
- Media related to at Wikimedia Commons
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- Soy Flours
- Textured Soy Proteins
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- Pollack, Andrew (May 21, 2012). "An Entrepreneur Bankrolls a Genetically Engineered Salmon".
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- California Proposition 37 (2012)
- Genetic engineering
- Genetically modified crops
- Genetically modified food controversies
- Genetically modified organisms
- Pharming (genetics) – use of genetically modified mammals to produce drugs
- Regulation of the release of genetic modified organisms
- Starlink corn recall
In a January 2010 paper, the extraction and detection of DNA along a complete industrial soybean oil processing chain was described to monitor the presence of 
As of 2015, 64 countries required GMO labeling.
Some jurisdictions require that GM foods carry a label indicating that fact. In some case, the requirement depends on the relative quantify of the GMO in the product. A study that investigated voluntary labeling in South Africa found that 31% of products labeled as GMO-free had a GM content above 1.0%. In Canada and the USA labeling is voluntary, In Europe all food (including processed food) or feed that contains greater than 0.9% GMOs must be labelled.
In 1992 FDA published "Statement of Policy: Foods derived from New Plant Varieties." This statement is a clarification of FDA's interpretation of the Food, Drug, and Cosmetic Act with respect to foods produced from new plant varieties developed using recombinant deoxyribonucleic acid (rDNA) technology. FDA encouraged developers to consult with the FDA regarding any bioengineered foods in development. The FDA says developers routinely do reach out for consultations. In 1996 FDA updated consultation procedures.
In the US, three government organizations regulate GMOs. The FDA checks the chemical composition of organisms for potential allergens. The United States Department of Agriculture (USDA) supervises field testing and monitors the distribution of GM seeds. The United States Environmental Protection Agency (EPA) is responsible for monitoring pesticide usage, including plants modified to contain proteins toxic to insects. Like USDA, EPA also oversees field testing and the distribution of crops that have had contact with pesticides to ensure environmental safety. In 2015 the Obama administration announced that it would update the way the government regulated GM crops.
Governments assess and manage genetic engineering technology and GMO development and release. Marked differences separate the US and European countries. Regulation varies depending on the intended product use. For example, a crop not intended for food use is generally not reviewed by authorities responsible for food safety.
 The starting point for assessing GM food safety is to evaluate its
One study did not show statistically significant evidence of sponsorship conflict of interest influence on study outcomes, but did find author affiliation to be strongly correlated to study outcome, concluding that "articles where a COI was identified show a tendency to produce outcomes favorable to the associated commercial interests." US Right to Know has filed freedom-of-information requests to see correspondence for 40 US researchers. Their findings thus far show that researchers have accepted funding and trravel reimbursements without disclosure.
One particular concern, in regards to the environment, is that GMOs designed to decrease the problem with weeds aggravate it instead. Palmer amaranth is a weed that competes with cotton. A native of the southwest, it has traveled east and was first found resistant to glyphosate in 2006. Glyphosate-tolerant cotton was introduced in the 1990s.
Some medical and environmental groups claim that the potential long-term impact on human health have not been adequately assessed and propose mandatory labeling or a moratorium on such products. The European Network of Scientists for Social and Environmental Responsibility (ENSSER), disputes the claim of scientific consensus on the relative safety of GM food, and that research issues due to intellectual property rights, limited access to research material, differences in methods, analysis and the interpretation of data, it is not possible to state whether GMOs are generally safe or unsafe, and instead must be a judged on case-by-case basis. The Institute of Medicine and the National Research Council also determined that GM food safety needs to be assessed on a case-by-case basis, and noted the limited ability of scientists to predict "adverse consequences of genetic change".
Labeling of GMO products in the marketplace is required in 64 countries. However, the US does not require this. The FDA's policy is to require a label only given significant differences in composition or health impacts. They have not identified such differences in any food currently approved for sale.
.SpringerOpen in 2014, published by Environmental Sciences Europe But Séralini defended his study and republished the same findings in  Sprague-Dawley rats are known to develop tumours even under normal conditions.) to make any conclusive evidence on the adverse effect of GM on the rats.Sprague-Dawley rats, on the ground that the study consisted of a limited number of test samples (Elsevier After reanalyses of the results, and the paper was retracted by the publisher,  However, the
There is general scientific agreement that food on the market from genetically modified crops is not inherently riskier to human health than conventional food.
Additional concerns include the impacts of conflicts of interest on research outcomes.  and control of the food supply by GM seed companies. rigor of the regulatory process pesticide resistance, farmers and on global food supplies. Other concerns include contamination of the conventional food supply, The genetically modified foods controversy is a dispute over the use of food and other products derived from
Some mammals typically used for food production have been modified to produce non-food products, a practice sometimes called Pharming.
A 2003 review published on behalf of Food Standards Australia New Zealand examined transgenic experimentation on terrestrial livestock species as well as aquatic species such as fish and shellfish. The review examined the molecular techniques used for experimentation as well as techniques for tracing the transgenes in animals and products as well as issues regarding transgene stability.
As of November 2013 no genetically modified animals had been approved for use as food. A GM salmon has been awaiting regulatory approval since 1997.
In some countries, recombinant (GM) American Medical Association, American Dietetic Association and the National Institutes of Health have independently stated that dairy products and meat from rBST-treated cows are safe for human consumption. However, on 30 September 2010, the United States Court of Appeals, Sixth Circuit, analyzing submitted evidence, found a "compositional difference" between milk from rBGH-treated cows and milk from untreated cows. The court stated that milk from rBGH-treated cows has: increased levels of the hormone Insulin-like growth factor 1 (IGF-1); higher fat content and lower protein content when produced at certain points in the cow's lactation cycle; and more somatic cell counts, which may "make the milk turn sour more quickly."
FPC was the first artificially produced enzyme to be approved by the US Food and Drug Administration. FPC products have been on the market since 1990 and as of 2015 had yet to be surpassed in commercial markets. In 1999, about 60% of US hard cheese was made with FPC. Its global market share approached 80%. By 2008, approximately 80% to 90% of commercially made cheeses in the US and Britain were made using FPC. The most widely used FPC is produced either by the fungus Aspergillus niger (CHY-MAX®)
. Trace quantities of chymosin may remain in cheese.whey The majority of the applied chymosin is retained in the 
A 2012 literature review of studies evaluating the effect of GM feed on the health of animals did not find evidence that animals were adversely affected, although small biological differences were occasionally found. The studies included in the review ranged from 90 days to two years, with several of the longer studies considering reproductive and intergenerational effects.
Livestock and poultry are raised on animal feed, much of which is composed of the leftovers from processing crops, including GM crops. For example, approximately 43% of a canola seed is oil. What remains after oil extraction is a meal that becomes an ingredient in animal feed and contains canola protein. Likewise, the bulk of the soybean crop is grown for oil and meal. The high-protein defatted and toasted soy meal becomes livestock feed and dog food. 98% of the US soybean crop goes for livestock feed. In 2011, 49% of the US maize harvest was used for livestock feed (including the percentage of waste from distillers grains). "Despite methods that are becoming more and more sensitive, tests have not yet been able to establish a difference in the meat, milk, or eggs of animals depending on the type of feed they are fed. It is impossible to tell if an animal was fed GM soy just by looking at the resulting meat, dairy, or egg products. The only way to verify the presence of GMOs in animal feed is to analyze the origin of the feed itself."
Most vegetable oil used in the US is produced from GM crops canola, corn, cotton and soybeans. Vegetable oil is sold directly to consumers as cooking oil, shortening and margarine and is used in prepared foods. There is a vanishingly small amount of protein or DNA from the original crop in vegetable oil. Vegetable oil is made of triglycerides extracted from plants or seeds and then refined and may be further processed via hydrogenation to turn liquid oils into solids. The refining process removes all, or nearly all non-triglyceride ingredients.
Independent analyses conducted by internationally recognized laboratories found that sugar from Roundup Ready sugar beets is identical to the sugar from comparably grown conventional (non-Roundup Ready) sugar beets. And, like all sugar, sugar from Roundup Ready sugar beets contains no genetic material or detectable protein (including the protein that provides glyphosate tolerance). These results were validated with the sugar derived from a 2007 commercial-scale processing of Roundup Ready sugar beets.
The US imports 10% of its sugar, while the remaining 90% is extracted from sugar beet and sugarcane. After deregulation in 2005, glyphosate-resistant sugar beet was extensively adopted in the United States. 95% of beet acres in the US were planted with glyphosate-resistant seed in 2011. Herbicide-tolerant beets are approved in Australia, Canada, Colombia, EU, Japan, Korea, Mexico, New Zealand, Philippines, Russian Federation and Singapore. Pulp from the refining process is used as animal feed. The sugar produced from GM sugarbeets contains no DNA or protein—it is just sucrose that is chemically indistinguishable from sugar produced from non-GM sugarbeets.
 Sufficiently processed lecithin is often undetectable with standard testing practices. According to the FDA, no evidence shows or suggests hazard to the public when lecithin is used at common levels. Lecithin added to foods amounts to only 2 to 10 percent of the 1 to 5 g of phosphoglycerides consumed daily on average. Nonetheless, consumer concerns about GM food extend to such products. This concern led to policy and regulatory changes in Europe in 2000, when Regulation (EC) 50/2000 was passed which required labelling of food containing additives derived from GMOs, including lecithin. Because of the difficulty of detecting the origin of derivatives like lecithin with current testing practices, European regulations require those who wish to sell lecithin in Europe to employ a comprehensive system of Identity preservation (IP).
- Maltodextrin, a lightly hydrolyzed starch product used as a bland-tasting filler and thickener.
- Various glucose syrups, also called corn syrups in the US, viscous solutions used as sweeteners and thickeners in many kinds of processed foods.
- Dextrose, commercial glucose, prepared by the complete hydrolysis of starch.
- High fructose syrup, made by treating dextrose solutions with the enzyme glucose isomerase, until a substantial fraction of the glucose has been converted to fructose. In the US, high fructose corn syrup is the principal sweetener used in sweetened beverages because fructose has better handling characteristics, such as microbiological stability, and more consistent sweetness/flavor. One kind of high fructose corn syrup, HFCS-55, is typically sweeter than regular sucrose because it is made with more fructose, while the sweetness of HFCS-42 is on par with sucrose.
- Sugar alcohols, such as maltitol, erythritol, sorbitol, mannitol and hydrogenated starch hydrolysate, are sweeteners made by reducing sugars.
Starch can be further modified to create modified starch for specific purposes, including creation of many of the sugars in processed foods. They include:
Starch or amylum is a polysaccharide produced by all green plants as an energy store. Pure starch is a white, tasteless and odourless powder. It consists of two types of molecules: the linear and helical amylose and the branched amylopectin. Depending on the plant, starch generally contains 20 to 25% amylose and 75 to 80% amylopectin by weight.
Corn starch and starch sugars, including syrups
Textured soy protein (TSP) is a fibrous, spongy matrix similar in texture to meat. TSP is used as a low-cost substitute in meat and poultry products.
Soy flour is made by grinding soybeans into a fine powder. It comes in three forms: natural or full-fat (contains natural oils); defatted (oils removed) with 50% protein content and with either high water solubility or low water solubility; and lecithinated (lecithin added). As soy flour is gluten-free, yeast-raised breads made with soy flour are dense in texture. Soy grits are similar to soy flour except the soybeans have been toasted and cracked into coarse pieces. Kinako is a soy flour used in Japanese cuisine.
Soy protein concentrate is about 70% soy protein and is basically soybean meal without carbohydrates. Soy protein concentrate retains most of the bean fiber. It is used as a functional or nutritional ingredient in food products, mainly in baked foods, breakfast cereals and in some meat products. Soy protein concentrate is used in meat and poultry products to increase water and fat retention and to improve nutritional values (more protein, less fat).
Food-grade soy protein isolate first became available on October 2, 1959.:227–28 Soy protein isolate is a highly refined form of soy protein with a minimum protein content of 90% on a moisture-free basis. It is made from soy meal that has had most of the fats and carbohydrates removed. Soy isolates are mainly used to improve the texture of processed meat products and to increase protein content, enhance moisture retention and as an emulsifier.
Genetically modified soybean has been modified to tolerate herbicides, express Bt and produce healthier oils. In 2015, 94% of soybean acreage in the U.S. was genetically modified to be glyphosate-tolerant. Soybeans contain about 20% oil. In the most common method used to extract the oil, the soybeans are cracked, adjusted for moisture content, rolled into flakes and solvent-extracted with commercial hexane. The remaining soy meal has a 50% soy protein content. The meal is 'toasted' (actually heated with moist steam) and ground in a hammer mill. Part of the balance is processed further into high protein soy products that are used in a variety of foods, such as salad dressings, soups, meat analogues, beverage powders, cheeses, nondairy creamer, frozen desserts, whipped topping, infant formulas, breads, breakfast cereals, pasta and pet foods. Processed soy protein appears in foods mainly in three forms: soy flour, soy protein isolates and soy protein concentrates.
Corn used for food and ethanol has been genetically modified to tolerate various herbicides and to express a protein from Bacillus thuringiensis (Bt) that kills certain insects. About 90% of the corn grown in the U.S. was genetically modified in 2010. In the US in 2015, 81% of corn acreage contained the Bt trait and 89% of corn acreage contained the glyphosate-tolerant trait. Corn can be processed into grits, meal and flour as an ingredient in pancakes, muffins, doughnuts, breadings and batters, as well as baby foods, meat products, cereals and some fermented products. Corn-based masa flour and masa dough are used in the production of taco shells, corn chips and tortillas.
In February 2015 Arctic Apples were approved by the USDA, becoming the first genetically modified apple approved for sale in the US. Gene silencing is used to reduce the expression of polyphenol oxidase (PPO), thus preventing the fruit from browning.
In 2014, the USDA approved a genetically modified potato developed by J.R. Simplot Company that contained ten genetic modifications that prevent bruising and produce less acrylamide when fried. The modifications eliminate specific proteins from the potatoes, via RNA interference, rather than introducing novel proteins.
In 2013, the USDA approved the import of a GM pineapple that is pink in color and that "overexpresses" a gene derived from tangerines and suppress other genes, increasing production of lycopene. The plant's flowering cycle was changed to provide for more uniform growth and quality. The fruit "does not have the ability to propagate and persist in the environment once they have been harvested," according to USDA APHIS. According to Del Monte's submission, the pineapples are commercially grown in a "monoculture" that prevents seed production, as the plant's flowers aren't exposed to compatible pollen sources. Importation into Hawaii is banned for "plant sanitation" reasons.
In 2011, BASF requested the European Food Safety Authority's approval for cultivation and marketing of its Fortuna potato as feed and food. The potato was made resistant to late blight by adding resistant genes blb1 and blb2 that originate from the Mexican wild potatoSolanum bulbocastanum. In February 2013, BASF withdrew its application.
The New Leaf potato, brought to market by Monsanto in the late 1990s, was developed for the fast food market. It was withdrawn in 2001 after retailers rejected it and food processors ran into export problems.
 The GM cultivar was approved in 1998. In China, a transgenic PRSV-resistant papaya was developed by South China Agricultural University and was first approved for commercial planting in 2006; as of 2012 95% of the papaya grown in Guangdong province and 40% of the papaya grown in Hainan province was genetically modified.
Fruits and vegetables
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Once satisfactory strains are produced, the producer applies for regulatory approval to field-test them, called a "field release." Field-testing involves cultivating the plants on farm fields or growing animals in a controlled environment. If these field tests are successful, the producer applies for regulatory approval to grow and market the crop. Once approved, specimens (seeds, cuttings, breeding pairs, etc.) are cultivated and sold to farmers. The farmers cultivate and market the new strain. In some cases, the approval covers marketing but not cultivation.
Genetically engineered organisms are generated and tested in the laboratory for desired qualities. The most common modification is to add one or more genome. Less commonly, genes are removed or their expression is increased or silenced or the number of copies of a gene is increased or decreased.
In the US in 1995, the following transgenic crops received marketing approval: canola with modified oil composition (Calgene), Bacillus thuringiensis (Bt) corn/maize (Ciba-Geigy), cotton resistant to the herbicide bromoxynil (Calgene), Bt cotton (Monsanto), Bt potatoes (Monsanto), glyphosate-tolerant soybeans (Monsanto), virus-resistant squash (Monsanto-Asgrow), and additional delayed ripening tomatoes (DNAP, Zeneca/Peto, and Monsanto). In 2000, with the creation of golden rice, scientists genetically modified food to increase its nutrient value for the first time. As of 2011, the US is the leading country in the production of GM foods. Twenty-five GM crops had received regulatory approval. In 2015, 92% of corn, 94% of soybeans, and 94% of cotton produced in the US were genetically modified strains.
Genetically modified microbial enzymes were the first application of Food and Drug Administration. These included the protease chymosin for cheese production. Cheese had typically been made using the enzyme complex rennet that had been extracted from cows' stomach lining. Scientists modified bacteria to produce chymosin, which was also able to clot milk, resulting in cheese curds.
In 1944, Avery, McCarty, and MacLeod demonstrated that nucleic acids carried the genetic material of cells and could be passed between organisms. The first genetically modified plant was produced in 1983, using antibiotic-resistant tobacco. In 1994, the transgenic Flavr Savr tomato was approved by the FDA for marketing in the US. The modification allowed the tomato to delay ripening after picking. In the early 1990s, recombinant chymosin was approved for use in several countries.
 was applied to milk, to improve food safety.pasteurization discovered that heating juices to a certain temperature kills dangerous bacteria, affecting wine and fermentation. The eponymous Louis Pasteur In 1871