MIP (gene)

Major intrinsic protein of lens fiber
PDB rendering based on 1sor.
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

Lens fiber major intrinsic protein is a protein that in humans is encoded by the MIP gene.[1][2][3]


Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13.[3]


Further reading