Methuselah-like proteins

Methuselah-like proteins

Methuselah N-terminus
Identifiers
Symbol Methuselah_N
Pfam InterPro IPR010596
SCOP SUPERFAMILY 1fjr

The Methuselah-like proteins are a family of G protein-coupled receptors found in insects that play a role in aging and reproduction. Antagonizing these receptors can extend the life span of the animal and make it more resistant to free radicals and starvation, but also reduce reproduction and increase cold sensitivity. The age dependent decline in olfaction and motor function is unaffected.[2]

Methuselah-like proteins are related to G protein-coupled receptors of the secretin receptor family.[1]

References