Muscarinic acetylcholine receptor m1

Cholinergic receptor, muscarinic 1
Identifiers
CHRM1 Gene
Orthologs
SpeciesHumanMouse

The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor.

This receptor is found mediating slow EPSP at the ganglion in the postganglionic nerve,[1] is common in exocrine glands and in the CNS.[2][3]

It is predominantly found bound to G proteins of class Gq[4] that use upregulation of phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signalling pathway. A receptor so bound would not be susceptible to CTX or PTX. However, Gi (causing a downstream decrease in cAMP) and Gs (causing an increase in cAMP) have also been shown to be involved in interactions in certain tissues, and so would be susceptible to PTX and CTX respectively.

Effects

Mechanism

It couples to Gq, and, to a small extent, Gi and Gs. This results in slow EPSP and decreased K+ conductance[6][7]

Ligands

Agonists

Allosteric modulators

  • benzylquinolone carboxylic acid[8]
  • VU-0090157[9]
  • VU-0029767[9]

Antagonists

Gene

The receptor is encoded by human gene CHRM1.[5] It is localized to 11q13.[5]

See also

References

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.