Prostaglandin E synthase
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

Prostaglandin E synthase is an enzyme that in humans is encoded by the PTGES gene.[1][2][3]

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53-induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.[3]

See also


Further reading