Parathyroid hormone receptor

Parathyroid hormone receptor

parathyroid hormone 1 receptor
Identifiers
Symbol PTH1R
Alt. symbols PTHR, PFE
Entrez 5745
HUGO 9608
OMIM 168468
RefSeq NM_000316
UniProt Q03431
Other data
Locus Chr. 3 p22-p21.1
parathyroid hormone 2 receptor
Identifiers
Symbol PTH2R
Entrez 5746
HUGO 9609
OMIM 601469
RefSeq NM_005048
UniProt P49190
Other data
Locus Chr. 2 q33

There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins.[1]

References

  1. ^ Jüppner H (1994). "Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors". Curr. Opin. Nephrol. Hypertens. 3 (4): 371–8.  
  2. ^ Mannstadt M, Jüppner H, Gardella TJ (1999). "Receptors for PTH and PTHrP: their biological importance and functional properties". Am. J. Physiol. 277 (5 Pt 2): F665–75.  
  3. ^ Offermanns S, Iida-Klein A, Segre GV, Simon MI (1996). "G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells". Mol. Endocrinol. 10 (5): 566–74.  
  4. ^ Usdin TB, Bonner TI, Hoare SR (2002). "The parathyroid hormone 2 (PTH2) receptor". Recept. Channels 8 (3–4): 211–8.  

External links

  • Parathyroid Hormone Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
  • "Parathyroid Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.