Prostacyclin receptor
Prostaglandin I2 (prostacyclin) receptor (IP) | |||||||||||||
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Identifiers | |||||||||||||
PTGIR Gene | |||||||||||||
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RNA expression pattern | |||||||||||||
Prostacyclin receptor ( or prostaglandin I2 receptor, IP1) is a receptor for prostacyclin.
It is a member of the G-protein coupled receptor family. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.[1]
Contents
Transduction
When binding a prostacyclin-molecule, the receptor changes conformation and activates Gs, with its activation of cAMP and increase in protein kinase A (PKA) activity.
In vasodilation
In vasodilation, the PKA activity causes phosphorylation of MLCK, decreasing its activity, resulting in dephosphorylation of MLC of myosin. The smooth muscle relaxation leads to vasodilation.[2]
Gene
The receptor is encoded by the human gene PTGIR.[1]
See also
References
External links
Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.