Retinal G protein coupled receptor

Retinal G protein coupled receptor
RGR Gene
RNA expression pattern

RPE-retinal G protein-coupled receptor is a protein that in humans is encoded by the RGR gene.[1][2]

Defects in this gene are a cause of retinitis pigmentosa. The gene is a member of the rhodopsin-like receptor subfamily of GPCR. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein presumably acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal, similar to retinochrome in invertebrates. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.[2]


Retinal G protein coupled receptor has been shown to interact with KIAA1279.[3]


Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.