Retinoic acid-inducible orphan G protein-coupled receptor

G protein-coupled receptor, family C, group 5, member A
Identifiers
Symbol GPRC5A
Alt. symbols RAIG1, RAI3
Entrez HUGO OMIM RefSeq UniProt Locus p13-p12.3
G protein coupled receptor, family C, group 5, member B
Identifiers
Symbol GPRC5B
Alt. symbols RAIG2
Entrez HUGO OMIM RefSeq UniProt Locus p12
G protein-coupled receptor, family C, group 5, member C
Identifiers
Symbol GPRC5C
Alt. symbols RAIG3
Entrez HUGO OMIM RefSeq UniProt Locus q25
G protein-coupled receptor, family C, group 5, member D
Identifiers
Symbol GPRC5D
Entrez HUGO OMIM RefSeq UniProt Locus p13.3

The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression is induced by retinoic acid.[1][2][3][4]

The exact function of these proteins has not been determined but they may provide a mechanism by which retinoic acid can influence G protein signal transduction cascades. In addition, RAIG receptors interact with members of the frizzled class of G protein-coupled receptors and appear to activate the Wnt signaling pathway.[5]

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