SLCO1B3

SLCO1B3

Solute carrier organic anion transporter family, member 1B3
Identifiers
SLCO1B3 Gene
RNA expression pattern

Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.[1]

OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein.

Clinical significance

OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.[2] Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.[3]

In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.[3]

Substrates

Small molecules that are transported by SLCO1B3 include:[4]

See also

References

Further reading