2,5-Dimethoxy-4-trifluoromethylamphetamine

2,5-Dimethoxy-4-trifluoromethylamphetamine

2,5-Dimethoxy-4-trifluoromethylamphetamine
Systematic (IUPAC) name
(RS)-1-[2,5-Dimethoxy-4-(trifluoromethyl)phenyl]propan-2-amine
Identifiers
CAS Registry Number  N
159277-12-0 (hydrochloride)
PubChem CID:
ChemSpider  YesY
ChEMBL  YesY
Synonyms 2,5-Dimethoxy-4-trifluoromethylamphetamine
Chemical data
Formula C12H16F3NO2
Molecular mass 263.26 g/mol
 N   

2,5-Dimethoxy-4-trifluoromethylamphetamine (DOTFM) is a psychedelic drug of the phenethylamine and amphetamine chemical classes. It was first synthesized in 1994 by a team at Purdue University led by David E. Nichols.[1] DOTFM is the alpha-methylated analogue of 2C-TFM, and is around twice as potent in animal studies. It acts as an agonist at the 5HT2A and 5HT2C receptors.[1] In drug-substitution experiments in rats, DOTFM fully substituted for LSD and was slightly more potent than DOI.[1]

See also

References

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