Systematic (IUPAC) name
Clinical data
Legal status
CAS Registry Number (freebase) 79295-51-5 (hydrochloride)
PubChem CID:
Chemical data
Formula C17H25NO
Molecular mass 259.39

3-Hydroxyphencyclidine (3-HO-PCP) is a dissociative anesthetic that has been sold online as a designer drug.[1] 3-HO-PCP binds to the NMDA and opioid receptors.[2][3][4][5][6][7][8][9]

On October 18, 2012 the Advisory Council on the Misuse of Drugs in the United Kingdom released a reportabout methoxetamine, saying that the "harms of methoxetamine are commensurate with Class B of the Misuse of Drugs Act (1971)", despite the fact that the act does not classify drugs based on harm. The report went on to suggest that all analogues of MXE should also become class B drugs and suggested a catch-all clause covering both existing and unresearched arylcyclohexamines, including 3-HO-PCP.[10]

See also


  1. ^ Morris, H.; Wallach, J. (2014). "From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs". Drug Testing and Analysis 6: 614–632.  
  2. ^ Yossef Itzhak (1986). H-PCP-analog."3"High and low affinity psychotomimetic opioid binding sites: characterization by a novel (PDF). NIDA Research Morograph 75: 173–176.  
  3. ^ J. M. Kamenka, B. Chiche, R. Goudal, P. Geneste, J. Vignon, J. P. Vincent, M. Lazdunski (April 1982). "Chemical synthesis and molecular pharmacology of hydroxylated 1-(1-phenylcyclohexyl)piperidine derivatives". Journal of Medicinal Chemistry 25 (4): 431–435.  
  4. ^ Yossef Itzhak, Asher Kalir, Yosef Sarne (July 1981). "On the opioid nature of phencyclidine and its 3-hydroxy derivative". European Journal of Pharmacology 73 (2–3): 229–233.  
  5. ^ Nicole Johnson, Yossef Itzhak, Gavril W. Pasternak (June 1984). H-opioid binding sites"3"Interaction of two phencyclidine opiate-like derivatives with . European Journal of Pharmacology 101 (3–4): 281–284.  
  6. ^ Yossef Itzhak (1988). "Pharmacological specificity of some psychotomimetic and antipsychotic agents for the sigma and PCP binding sites". Life Sciences 42 (7): 745–752.  
  7. ^ Yossef Itzhak (April 1987). H]SKF 10047 binding sites in rat brain membranes: evidence of multiplicity"3H]PCP-3-OH and (+)[3"[. European Journal of Pharmacology 136 (2): 231–234.  
  8. ^ Yossef Itzhak, Mabda Khouri (February 1988). "Regulation of the binding of σ- and phencyclidine (PCP)-receptor ligands in rat brain membranes by guanine nucleotides and ions". Neuroscience Letters 85 (1): 147–152.  
  9. ^ Toshihito Suzuki, Toshifumi Yamamoto, Takafumi Hori, Shuzo Abe, Takashi Moroji, Hiroyasu Shiraishi, Takehiko Ito, Ing Kang Ho (1995). H]3-OH-PCP (1-(1(3-Hydroxyphenyl)cyclohexyl)piperidine) binding sites in rat brain"3"Quantitative autoradiographic localization of [. Brain Research Bulletin 37 (4): 431–435.  
  10. ^ "(ACMD) Methoxetamine Report (2012)" (PDF). UK Home Office. 2012-10-18. p. 14. Retrieved 2015-06-24.