4-Fluoromethamphetamine

4-Fluoromethamphetamine

4-Fluoromethamphetamine
Systematic (IUPAC) name
(RS)-1-(4-fluorophenyl)-N-methylpropan-2-amine
Clinical data
Legal status
?
Identifiers
CAS number  N
52063-62-4 (hydrochloride)
ATC code ?
PubChem
ChemSpider  YesY
Chemical data
Formula C10H14FN 
Mol. mass 167.223
 N   

4-Fluoromethamphetamine (4-FMA) is a 2-fluoromethamphetamine.[3]

Pharmacology

4-FMA is a CYP450 inhibitor. It reduces the metabolism of methamphetamine, which has the effect of increasing its potency, duration and systemic toxicity while also reducing its cellular toxicity.[4][5]

See also

References

  1. ^ Rösner, P.; Quednow, B.; Girreser, U.; Junge, T. (2005). "Isomeric Fluoro-methoxy-phenylalkylamines: A new series of controlled-substance analogues (designer drugs)". Forensic Science International 148 (2–3): 143–156.  
  2. ^ Machiko Nagashima, Takako Seto, Misako Takahashi, Jin Suzuki, and Ichirou Yasuda (2006). "Spectrum Data of the 3rd Governor-designated Drugs and the Analyses of Uncontrolled Drugs Purchased". Ann. Rep. Tokyo Metr. Inst.P.H. 57: 109–113. 
  3. ^ Camilleri, A; Johnston, MR; Brennan, M; Davis, S; Caldicott, DG (2010). "Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone". Forensic Science International 197 (1–3): 59–66.  
  4. ^ Cherner, M.; Bousman, C.; Everall, I. A. N.; Barron, D.; Letendre, S.; Vaida, F.; Atkinson, J. H.; Heaton, R.; Grant, I.; Hnrc, G. (2010). "Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: Preliminary findings". Journal of the International Neuropsychological Society 16 (5): 890–901.  
  5. ^ Taniguchi, Masashi; Yamamoto, Yoshio; Nishi, Katsuji (2013). Studies of the Metabolism of Six 4-Substituted Methamphetamines and Their Inhibition of Cytochrome P450 2D6 by GC-MS with Trifluoroacetyl Derivatization"in Vitro"Comparative . American Journal of Analytical Chemistry 04 (4): 166.