4-hydroxyphenylpyruvic acid

4-Hydroxyphenylpyruvic acid
Identifiers
CAS number 156-39-8 N
PubChem 979
ChemSpider 954 YesY
DrugBank DB07718
KEGG C01179 YesY
ChEBI CHEBI:15999 YesY
Jmol-3D images Image 1
Properties
Molecular formula C9H8O4
Molar mass 180.157 g/mol
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

4-Hydroxyphenylpyruvic acid (4-HPPA) is an intermediate in the metabolism of the amino acid phenylalanine. The aromatic side chain of phenylalanine is hydroxylated by the enzyme phenylalanine hydroxylase to form tyrosine. The conversion from tyrosine to 4-HPPA is in turn catalyzed by tyrosine aminotransferase.[1] Additionally, 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment.[2]

It is an intermediary compound in the biosynthesis of scytonemin.

See also

References