5'-Guanidinonaltrindole

5'-Guanidinonaltrindole

5'-Guanidinonaltrindole
Systematic (IUPAC) name
5'-Guanidinyl-17-(cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan
Identifiers
CAS Registry Number  YesY
PubChem CID:
IUPHAR/BPS
ChemSpider  N
ChEMBL  N
Synonyms 5'-Guanidinonaltrindole, GNTI
Chemical data
Formula C27H29N5O3
Molecular mass 471.550 g/mol
 N   

5'-Guanidinonaltrindole (5'-GNTI) is an opioid antagonist used in scientific research which is highly selective for the κ opioid receptor. It is 5x more potent and 500 times more selective than the commonly used κ-opioid antagonist norbinaltorphimine.[1] It has a slow onset and long duration of action,[2][3] and produces antidepressant effects in animal studies.[4] It also increases allodynia by interfering with the action of the κ-opioid peptide dynorphin.[5]

See also

References

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