5-(Nonyloxy)tryptamine

5-(Nonyloxy)tryptamine

5-(Nonyloxy)tryptamine
Systematic (IUPAC) name
2-(5-nonyloxy-1H-indol-3-yl)ethanamine
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code ?
PubChem
Chemical data
Formula C19H30N2O 
Mol. mass 302.453 g/mol
 YesY   

5-(Nonyloxy)tryptamine is a tryptamine derivative which acts as a selective agonist at the 5-HT1D serotonin receptor. Increasing the O-alkoxy chain length in this series gives generally increasing potency and selectivity for 5-HT1D, with highest activity found for the nonyloxy derivative, having a 5-HT1D binding affinity of 1.0nM, and around 300x selectivity over the related 5-HT1A receptor.[1][2]

See also

References

  1. ^ Glennon RA, Hong SS, Dukat M, Teitler M, Davis K (September 1994). "5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist". Journal of Medicinal Chemistry 37 (18): 2828–30.  
  2. ^ Glennon RA, Hong SS, Bondarev M, Law H, Dukat M, Rakhi S, Power P, Fan E, Kinneau D, Kamboj R, Teitler M, Herrick-Davis K, Smith C (January 1996). "Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors". Journal of Medicinal Chemistry 39 (1): 314–22.