(2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4- thia-1-azabicyclo[3.2.0]heptane-2- carboxylic acid
|Molar mass||216.257 g/mol|
|Melting point||198 °C (388 °F; 471 K)|
|Boiling point||207 °C (405 °F; 480 K) decomp|
|0.4 g/100 mL|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
6-APA is the chemical compound (+)-6-aminopenicillanic acid.
In 1958, Beecham scientists in the UK discovered the penicillin nucleus, 6-APA. From that starting material, a large number of new semisynthetic penicillins could be designed, whose activity was directed against problem infections.
- , 257-258 (24 January 1959)183 NatureSynthesis of Penicillin: 6-Aminopenicillanic Acid in Penicillin Fermentations - F. R. Batchelor, F. P. Doyle, J. H. C. Nayler & G. N. Rolinson. doi:10.1038/183257b0
- F.P. Doyle, J.H.C. Nayler, G.N. Rolinson US Patent 2,941,995, filed July 22, 1958, granted June 21, 1960. Recovery of solid 6-aminopenicillanic acid.
- US patent 2,941,995 on espacenet