6-Fluoronorepinephrine

6-Fluoronorepinephrine

6-Fluoronorepinephrine
Systematic (IUPAC) name
4-(2-amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol
Clinical data
Legal status
  • Uncontrolled
Identifiers
CAS number  N
ATC code None
PubChem
IUPHAR ligand
ChemSpider  YesY
ChEMBL  YesY
Chemical data
Formula C8H10FNO3 
Mol. mass 187.17 g/mol
 N   

6-Fluoronorepinephrine (6-FNE) is a selective α1- and α2-adrenergic receptor full agonist related to norepinephrine.[1][2] It is the only selective full agonist for the α-adrenergic receptors known to date and has been used to study their function in scientific research.[2] Infusion of 6-FNE into the locus coeruleus of rodents produces marked hyperactivity and behavioral disinhibition by suppressing activity in the area via stimulation of α1-adrenergic receptors.[2][3]

References

  1. ^ Kirk KL, Cantacuzene D, Nimitkitpaisan Y, McCulloh D, Padgett WL, Daly JW, Creveling CR (1979). "Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines". Journal of Medicinal Chemistry 22 (12): 1493–7.  
  2. ^ a b c Stone EA, Lin Y, Sarfraz Y, Quartermain D (2009). -adrenoceptors by a full agonist"1"Marked behavioral activation from inhibitory stimulation of locus coeruleus α. Brain Research 1291: 21–31.  
  3. ^ Stone EA, Grunewald GL, Lin Y, Ahsan R, Rosengarten H, Kramer HK, Quartermain D (2003). "Role of epinephrine stimulation of CNS α1-adrenoceptors in motor activity in mice". Synapse 49 (1): 67–76.