A-366,833

A-366,833

A-366,833
Systematic (IUPAC) name
5-[(1S,5R)-3,6-diazabicyclo[3.2.0]hept-6-yl]pyridine-3-carbonitrile
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code ?
PubChem
ChemSpider  YesY
ChEMBL  YesY
Chemical data
Formula C11H12N4 
Mol. mass 200.239
 YesY   

A-366,833 is a drug developed by Abbott, which acts as an agonist at neural nicotinic acetylcholine receptors selective for the α4β2 subtype, and has been researched for use as an analgesic, although it has not passed clinical trials.[1][2]

References

  1. ^ Ji, J.; Bunnelle, W.; Anderson, D.; Faltynek, C.; Dyhring, T.; Ahring, P.; Rueter, L.; Curzon, P.; Buckley, M.; Marsh, K. C.; Kempf-Grote, A.; Meyer, M. D. (2007). "A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo3.2.0-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models". Biochemical pharmacology 74 (8): 1253–1262.  
  2. ^ Romanelli, M.; Gratteri, P.; Guandalini, L.; Martini, E.; Bonaccini, C.; Gualtieri, F. (2007). "Central nicotinic receptors: structure, function, ligands, and therapeutic potential". ChemMedChem 2 (6): 746–767.  

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