A-412,997

A-412,997

A-412,997
Systematic (IUPAC) name
N-(3-methylphenyl)-2-(4-pyridin-2-ylpiperidin-1-yl)acetamide
Identifiers
PubChem CID:
IUPHAR/BPS
ChemSpider  YesY
ChEMBL  YesY
Chemical data
Formula C19H23N3O
Molecular mass 309.405 g/mol
 YesY   

A-412,997 is a drug which acts as a dopamine agonist that is used in scientific research. It is the first drug developed that is a highly selective agonist for the D4 subtype, with significantly improved selectivity over older D4-preferring compounds such as PD-168,077 and CP-226,269.[1] In animal tests it improved cognitive performance in rats to a similar extent as methylphenidate, but without producing place preference or other signs of abuse liability.[2][3] Also unlike other dopamine agonists, selective D4 agonists do not cause side effects such as sedation and nausea, and so might have advantages over older dopamine agonist drugs.[4]

References

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