ACCN1

ACCN1

Acid-sensing (proton-gated) ion channel 2
Identifiers
ASIC2 Gene
RNA expression pattern

Amiloride-sensitive cation channel 1, neuronal is a protein that in humans is encoded by the ACCN1 gene.[1][2]

Function

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.[2]

See also

References

Further reading