ACCN3

ACCN3

Acid-sensing (proton-gated) ion channel 3
Identifiers
ASIC3 Gene
Orthologs
SpeciesHumanMouse

Amiloride-sensitive cation channel 3 is a protein that in humans is encoded by the ACCN3 gene.[1][2][3]

Function

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium. Alternative splicing of this gene generates three transcript variants encoding distinct isoforms.[3]

Interactions

ACCN3 has been shown to interact with LIN7B,[4] GOPC[4] and MAGI1.[4]

See also

References

Further reading