AM-2233

AM-2233

AM-2233
Systematic (IUPAC) name
1-[(N-methylpiperidin-2-yl)methyl]-3-(2-iodobenzoyl)indole
Clinical data
Legal status
Identifiers
CAS Registry Number  N
PubChem CID:
ChemSpider  YesY
ChEMBL  YesY
Chemical data
Formula C22H23IN2O
Molecular mass 458.334 g/mol
 N   

AM-2233 is a drug that acts as a highly potent full agonist for the cannabinoid receptors, with a Ki of 1.8nM at CB1 and 2.2nM at CB2 as the active (R) enantiomer.[1] It was developed as a selective radioligand for the cannabinoid receptors and has been used as its 131I derivative for mapping the distribution of the CB1 receptor in the brain.[2][3][4][5][6][7] AM-2233 was found to fully substitute for THC in rats, with a potency lower than that of JWH-018 but higher than WIN 55,212-2.[8]

Legal Status

As of October 2015 AM-2233 is a controlled substance in China.[9]

See also

References

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