AM-679 (cannabinoid)

AM-679 (cannabinoid)

AM-679 (cannabinoid)
Systematic (IUPAC) name
(2-iodophenyl)(1-pentyl-1H-indol-3-yl)methanone
Identifiers
CAS Registry Number  N
ChemSpider  YesY
Chemical data
Formula C20H20INO
Molecular mass 417.283 g/mol
 N   

AM-679 is a drug that acts as a moderately potent agonist for the cannabinoid receptors, with a Ki of 13.5nM at CB1 and 49.5nM at CB2.[1] AM-679 was one of the first 3-(2-iodobenzoyl)indole derivatives that was found to have significant cannabinoid receptor affinity, and while AM-679 itself has only modest affinity for these receptors, it was subsequently used as a base to develop several more specialised cannabinoid ligands that are now widely used in research, including the potent CB1 agonists AM-694 and AM-2233, and the selective CB2 agonist AM-1241.[2] AM-679 was first identified as having been sold as a cannabinoid designer drug in Hungary in 2011, along with another novel compound 1-pentyl-3-(1-adamantoyl)indole.[3]

See also

References

  1. ^ WO patent 200128557, Makriyannis A, Deng H, "Cannabimimetic indole derivatives", granted 2001-06-07 
  2. ^
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