Adenosine A2b receptor
|Adenosine A2b receptor|
|RNA expression pattern|
This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation.
The gene is located near the Smith-Magenis syndrome region on chromosome 17.
Research into selective A2B ligands has lagged somewhat behind the development of ligands for the other three adenosine receptor subtypes, but a number of A2B-selective compounds have now been developed, and research into their potential therapeutic applications is ongoing.
- BAY 60-6583
- NECA (N-ethylcarboxamidoadenosine)
- (S)-PHPNECA - high affinity and efficacy at A2B, but poor selectivity over other adenosine receptor subtypes
- LUF-5845 - partial agonist
Antagonists and inverse agonists
- Compound 38: antagonist, high affinity and good subtype selectivity