Alnespirone

Alnespirone

Alnespirone
Systematic (IUPAC) name
(+)-4-dihydro-2H-chromen-3-yl]-propylamino]butyl]-8-azaspiro[4.5]decane-7,9-dione
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code None
PubChem
ChemSpider  YesY
UNII  YesY
ChEMBL
Chemical data
Formula C26H38N2O4 
Mol. mass 442.589 g/mol
 YesY   

Alnespirone (S-20,499) is a selective 5-HT1A receptor full agonist of the azapirone chemical class.[1][2][3] It has antidepressant and anxiolytic effects.[1]

See also

References

  1. ^ a b Griebel G, Misslin R, Pawlowski M, Guardiola Lemaître B, Guillaumet G, Bizot-Espiard J. (1992). "Anxiolytic-like effects of a selective 5-HT1A agonist, S20244, and its enantiomers in mice.". Neuroreport. 3 (1): 84–86.  
  2. ^ Simon P, Guardiola B, Bizot-Espiard J, Schiavi P, Costentin J. (1992). "5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists.". Psychopharmacology (Berl). 108 (1-2): 47–50.  
  3. ^ Astier B, Lambás Señas L, Soulière F, Schmitt P, Urbain N, Rentero N, Bert L, Denoroy L, Renaud B, Lesourd M, Muñoz C, Chouvet G. (2003). "In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity.". Eur J Pharmacol. 459 (1): 17–26.