Alpha-2A adrenergic receptor

Alpha-2A adrenergic receptor

Adrenoceptor alpha 2A
PDB rendering based on 1hll.
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

The alpha-2A adrenergic receptor2A adrenoceptor), also known as ADRA2A, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.[1]


Alpha-2-adrenergic receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mice revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity.


This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.[1]

Role in Central Nervous System

Although the pre-synaptic functions of alpha-2A receptors have been a major focus (see above), the majority of alpha-2 receptors in the brain are actually localized post-synapticly to noradrenergic terminals, and therefore aid in the function of norepinephrine. Many post-synaptic alpha-2A receptors have important effects on brain function; for example, alpha-2A receptors are localized on prefrontal cortical neurons where they regulate higher cognitive function.




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