Alpha-3 beta-4 nicotinic receptor

Alpha-3 beta-4 nicotinic receptor

The alpha-3 beta-4 nicotinic receptor, also known as the α3β4 receptor, is a type of nicotinic acetylcholine receptor, consisting of α3 and β4 subunits.[1][2] It is located in autonomic ganglia,[3] in adrenal medulla,[4] in the brain,[2] where activation yields post- and/or presynaptic excitation.

As with other nicotinic acetylcholine receptors, the α3β4 receptor is pentameric [(α3)m4)n where m + n = 5]. The exact subunit stoichiometry is not known and it is possible that more than one functional α3β4 receptor assembles in vivo with varying subunit stoichiometries.

Ligands

Agonists

Antagonists

Competitive

  • compound 5, highly selective over α4β2 and α7[7]

Noncompetitive

See also

References