Alpha-3 beta-4 nicotinic receptor
The alpha-3 beta-4 nicotinic receptor, also known as the α3β4 receptor, is a type of nicotinic acetylcholine receptor, consisting of α3 and β4 subunits. It is located in autonomic ganglia, in adrenal medulla, in the brain, where activation yields post- and/or presynaptic excitation.
As with other nicotinic acetylcholine receptors, the α3β4 receptor is pentameric [(α3)m(β4)n where m + n = 5]. The exact subunit stoichiometry is not known and it is possible that more than one functional α3β4 receptor assembles in vivo with varying subunit stoichiometries.
- Acetylcholine (endogenous neuromodulator that binds non-selectively to nAChRs and mAChRs.)
- compound 5, highly selective over α4β2 and α7
- Imipramine, K(d) = 0.41 μM