Anthelmintic

Anthelmintic

Anthelmintic effect of papain on Heligmosomoides bakeri.

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. They may also be called vermifuges (those that stun) or vermicides (those that kill). They are used to treat people or animals who are infected by helminths, a condition called helminthiasis.

Contents

  • Types 1
  • Anthelmintic resistance 2
  • See also 3
  • References 4
    • Footnotes 4.1
    • General references 4.2
  • External links 5

Types

Antiparasitics that specifically target Ascaris worms are called ascaricides.

Anthelmintic resistance

The ability of parasites to survive treatments that are generally effective at the recommended dose rate is a major threat to the future control of worm parasites in small ruminants and horses. This is especially true of nematodes, and has helped spur development of aminoacetonitrile derivatives for treatment against drug resistant nematodes.

The resistance is measured by the "Fecal egg count reduction" value which varies for different types of helminths.[2]

Treatment with an antihelminthic drug kills worms whose phenotype renders them susceptible to the drug. But resistant parasites survive and pass on their "resistance" genes. Resistant varieties accumulate and finally treatment failure occurs. See drug resistance.

See also

References

Footnotes

  1. ^ http://www.iasj.net/iasj?func=fulltext&aId=47308
  2. ^

General references

External links

  • Plant products in the treatment and control of filariasisand other helminth infections and assay systems for antifilarial/anthelminthic activity.
  • Holden-Dye, L. and Walker, R.J.Anthelmintic drugs (November 2, 2007), WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.143.1