Beta-3 adrenergic receptor

Beta-3 adrenergic receptor

Adrenoceptor beta 3
Available structures
PDB Ortholog search: RCSB
Identifiers
ADRB3 Gene
RNA expression pattern

The beta-3 adrenergic receptor3 adrenoreceptor), also known as ADRB3, is a beta-adrenergic receptor, and also denotes the human gene encoding it.[1]

Function

Actions of the β3 receptor include:

It is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Some β3 agonists have demonstrated antistress effects in animal studies, suggesting it also has a role in the central nervous system (CNS). Beta3-Receptors are found in the gallbladder, urinary bladder, and in brown adipose tissue. Their role in gallbladder physiology is unknown, but they are thought to play a role in lipolysis and thermogenesis in brown fat. In the urinary bladder it is thought to cause relaxation of the bladder and prevention of urination.[4]

Mechanism of action

Beta adrenergic receptors are involved in the epinephrine- and norepinephrine-induced activation of adenylate cyclase through the action of the G proteins of the type Gs.[1]

Agonists

  • Mirabegron (YM-178),[5] approved for treatment of overactive bladder in Japan, the United States, and Canada.
  • L-796,568[9]
  • CL-316,243[10]
  • LY-368,842
  • Ro40-2148

A selective β3 agonist has potential weight loss effects through modulation of lipolysis.[2]

Antagonists

See also

Interactions

Beta-3 adrenergic receptor has been shown to interact with Src.[13]

References

External links

Further reading