Bombesin-like receptor 3

Bombesin-like receptor 3

Bombesin-like receptor 3
BRS3 Gene
RNA expression pattern

The bombesin receptor subtype 3 also known as BRS-3 or BB3[1] is a protein which in humans is encoded by the BRS3 gene.[2][3]


Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).[3][4]

BB3 is a G protein-coupled receptor.[2] BB3 only interacts with known naturally-occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.[2][5][6]


Further reading

External links

  • Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.