Brain-specific angiogenesis inhibitor 3

Brain-specific angiogenesis inhibitor 3
Available structures
PDB Ortholog search: RCSB
BAI3 Gene

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.[1][2]

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.[2]

The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.[3] BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shwon to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.


Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.