Bursa of Fabricius

Bursa of Fabricius

In bone marrow is often both the site of hematopoiesis and B cell development. The bursa is present in the cloaca of birds and is named after Hieronymus Fabricius who described it in 1621.[1]

Contents

  • Description 1
  • Research history 2
  • Diseases 3
  • References 4
  • External links 5

Description

The bursa is an Dorsal diverticulum of the proctadael region of the cloaca. The luminal (interior) surface of the bursa is plicated with as many as 15 primary and 7 secondary plicae or folds. These plicae have hundreds of bursal follicles containing follicle-associated epithelial cells, lymphocytes, macrophages, and plasma cells. Lymphoid stem cells migrate from the fetal liver to the bursa during ontogeny. In the bursa, these stem cells acquire the characteristics of mature, immunocompetent B cells.

The bursa is active in young birds. It atrophies after about six months.[2]

Research history

In 1956, Bruce Glick showed that removal of the bursa in newly hatched chicks severely impaired the ability of the adult birds to produce antibodies.[3][4] In contrast, removal of the bursa in adult chickens has not much effect on the immune system. This was a serendipitous discovery that came about when a fellow graduate, Timothy S. Chang, who was teaching a course on antibody production obtained chickens from Glick that had been bursectomised (removal of the bursa). When these chickens failed to produce antibody in response to an immunization with Staphylococcus bacteria, the two students realized that the bursa is necessary for antibody production. Their initial attempts to publish their findings were thwarted by an editor who commented that "further elucidation of the mechanism ... should be attempted before publication.” [5]

The role of the thymus in the immune response was also identified shortly after the discovery of bursa’s role in antibody responses. In thymectomized animals, the ability to reject allografts, and to mount delayed hypersensitivity responses, was drastically reduced. By the mid-1960s, immunologists[6] were convinced that there were indeed two separate arms of the immune system: one dealing exclusively with the production of circulating antibodies (humoral immunity), and another that is involved in the delayed hypersensitivity-type reactions and graft rejections (cell-mediated immunity).

Diseases

Infectious Bursal Disease (IBD) is a viral disease in poultry. Typically, the virus attacks the bursa of young birds, preventing development of the immune system.

References

  1. ^ Ribatti D, Crivellato E, Vacca A (2006). "The contribution of Bruce Glick to the definition of the role played by the bursa of Fabricius in the development of the B cell lineage".  
  2. ^ http://www.nlm.nih.gov/cgi/mesh/2009/MB_cgi?mode=&term=Bursa+of+Fabricius
  3. ^ Glick, B; Chang, TS; Jaap, RG (1 January 1956). "The Bursa of Fabricius and Antibody Production". Poultry Science 35 (1): 224–225.  
  4. ^ Glick, B. (1983). The bursa of Fabricius. In "Avian Biology" Vol. 7 (D.S. Farner, J.R. King, and K.C.Parkes, Eds.). NewYork: Academic Press.
  5. ^ Sternberg, SS (Nov 2003). "Bottoms up to a Nobel-worthy chicken's bottom.". The American journal of surgical pathology 27 (11): 1471–2.  
  6. ^ Cooper, MD; Raymond, DA; Peterson, RD; South, MA; Good, RA (Jan 1, 1966). "The functions of the thymus system and the bursa system in the chicken.". The Journal of experimental medicine 123 (1): 75–102.  

External links

  • Bursa of Fabricius at the US National Library of Medicine Medical Subject Headings (MeSH)
  • Photo of diseased organ
  • Citation Classic